Mathematicians' brain motivated scientists for a long time. In general, they tried to understand the brain and the mechanics with which nerve cells and synapses can convert a set of information to theories, and what are the mental representations and the nervous structures that give the human brain, alone, the ability to explore the mathematical facts. A great potentiality opens clearly to science and especially, information sciences if possible to make an advance in this domain. We do not forget that the brain of the scientist Albert Einstein has been a subject of many researches that have been applied on it through his life and after his death in an attempt to understand the mechanisms of his scientific creativity. In the year 1985, one of the scientists in the University of Berckley managed to prove the existence of a high density of cells, more than usual, which forms the surrounding of the cortical cells in the frontal region of the cortex of Einstein's brain. In the year 1999, that is after forty years of Einstein's death, one of the scientists proved the existence of an unfamiliar malformation in the anatomical structure of this scientist's brain, and this malformation was big to a degree that an entire region of the cortex, which is the frontal counterpoint, was absent from the cortex. Though the importance of these researches, but they do not indicate anything clear for the cortex. On the other hand, scientists put a program for studying Mathematicians' brains comparatively. One of the scientists says that the mathematical tools certainly are identical with physical conditions in our brains, where in the end, they must be observed by an experimental way by means of developing brain imaging technics. Magnetic resonance imaging technics really allows reaching an experimental study to how the brain submits to the simplest mathematical tools that all human beings share, which is integers.